Atrophy definition pathology11/21/2023 When correcting for multiple comparisons (false discovery rate), differences that remained significant were occipital GM (CN Aβ-s vs AD Aβ+ ), hippocampus (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ), amygdala (CN Aβ-s vs CN Aβ+ and CN Aβ-s vs AD Aβ+ ), frontal GM (CN Aβ-s vs CN Aβ-d and CN Aβ-s vs AD Aβ+ ), cingulate GM (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ), temporal GM (CN Aβ-s vs CN Aβ+, CN Aβ-s vs AD Aβ+, and CN Aβ+ vs AD Aβ+ ), parietal GM (CN Aβ-s vs CN Aβ-d, CN Aβ-s vs CN Aβ+, and CN Aβ-s vs AD Aβ+ ), and overall GM (CN Aβ-s vs CN Aβ-d, CN Aβ-s vs CN Aβ+, CN Aβ-s vs AD Aβ+, and CN Aβ+ vs AD Aβ+ ). Significances are indicated for the effects of interaction between time and group (pairwise comparisons, comparing every group with the CN Aβ-s group and comparing the AD Aβ+ group with the CN Aβ+ group). Atrophy rates are modeled data from linear mixed-effects models (slopes), adjusted for age, sex, education, APOE ε4 genotype status, and intracranial volume. ![]() Shown are atrophy rates in the study groups. Aβ indicates β-amyloid AD, Alzheimer disease AD Aβ+, Aβ-positive AD group APOE, apolipoprotein E CN, cognitively normal CN Aβ+, Aβ-positive CN group CN Aβ-d, declining Aβ-negative CN group and CN Aβ-s, stable Aβ-negative CN group. When correcting for multiple comparisons (false discovery rate), differences that remained significant were amygdala (CN Aβ+ vs AD Aβ+ ), cingulate GM (CN Aβ+ vs AD Aβ+ ), overall GM (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ), hippocampus (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ), temporal lobe GM (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ), and parietal lobe GM (CN Aβ-s vs AD Aβ+ and CN Aβ+ vs AD Aβ+ ). Significances are indicated for the group effects (pairwise comparisons, comparing every group with the CN Aβ-s group and comparing the AD Aβ+ group with the CN Aβ+ group). Baseline volumes are modeled data from linear mixed-effects models (intercepts), adjusted for age, sex, education, APOE ε4 genotype status, and intracranial volume. Shown are baseline volumes in the study groups.
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